GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs7116495 | 1 | rs677279 | chr11:71770469 | FAM86C | chr11:71498557-71512276:+ | 0.32 | 3.91 | 0.000107 | Severe influenza A (H1N1) infection |
| THCA | cis | rs2243480 | 1 | rs67728539 | chr7:65378124 | CCT6P1 | chr7:65216092-65228661:+ | 0.38 | 5.99 | 4.15E-9 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs67728539 | chr7:65378124 | CRCP | chr7:65579805-65619551:+ | -0.26 | -3.95 | 8.96E-5 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs67728539 | chr7:65378124 | RABGEF1 | chr7:66093890-66276446:+ | 0.55 | 6.82 | 2.68E-11 | Diabetic kidney disease |
| THCA | cis | rs10935120 | 1 | rs6772896 | chr3:134203347 | ANAPC13 | chr3:134196547-134204865:- | 0.39 | 12.49 | 3.63E-31 | Height |
| THCA | cis | rs10935120 | 1 | rs6772896 | chr3:134203347 | CEP63 | chr3:134204575-134293852:+ | 0.3 | 6.35 | 4.92E-10 | Height |
| THCA | cis | rs237743 | 1 | rs67733885 | chr20:47896557 | DDX27 | chr20:47835832-47860612:+ | 0.26 | 4.81 | 2.03E-6 | Height |
| THCA | cis | rs6773957 | 1 | rs6773957 | chr3:186573705 | RTP4 | chr3:187086168-187089367:+ | 0.15 | 3.54 | 0.000433 | Adiponectin levels |
| THCA | cis | rs13191362 | 1 | rs67747005 | chr6:163150845 | PACRG | chr6:163148164-163736523:+ | 0.47 | 6.79 | 3.43E-11 | Body mass index |
| THCA | cis | rs7647973 | 1 | rs6774724 | chr3:49381911 | GMPPB | chr3:49758932-49761384:- | -0.16 | -3.59 | 0.000366 | Menarche (age at onset) |
| THCA | cis | rs7647973 | 1 | rs6774724 | chr3:49381911 | P4HTM | chr3:49027341-49044579:+ | 0.18 | 4.54 | 7.0E-6 | Menarche (age at onset) |
| THCA | cis | rs9815925 | 1 | rs6775591 | chr3:184743844 | C3orf70 | chr3:184795840-184870802:- | -0.23 | -4.68 | 3.82E-6 | Heschl's gyrus morphology |
| THCA | cis | rs9790314 | 1 | rs6775627 | chr3:160953609 | NMD3 | chr3:160939099-160971319:+ | -0.11 | -3.73 | 0.000218 | Morning vs. evening chronotype |
| THCA | cis | rs67766926 | 1 | rs67766926 | chr2:61163581 | C2orf74 | chr2:61372243-61391964:+ | 0.42 | 6.22 | 1.08E-9 | Inflammatory skin disease |
| THCA | cis | rs9876781 | 1 | rs6776700 | chr3:48496758 | ATRIP | chr3:48488141-48507708:+ | 0.19 | 4.14 | 4.15E-5 | Longevity |